Author: Jieyu Guo; Xiangxiang Wei; Qinhan Li; Liliang Li; Zhaohua Yang; Yu Shi; Yue Qin; Xinyue Zhang; Xinhong Wang; Xiuling Zhi; Dan Meng
Title: Single-cell RNA Analysis on ACE2 Expression Provides Insight into SARS-CoV-2 Blood Entry and Heart Injury Document date: 2020_4_4
ID: in3b1nzv_7
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03.31.20047621 doi: medRxiv preprint using published single-cell RNA-seq data. We found that ACE2 is mainly expressed in arterial vascular cells in fibrotic lungs, which might be essential for SARS-CoV-2 to enter the bloodstream and to start its circulatory spreading. We observed higher enrichment of ACE2 expression in cardiomyocytes of failed a.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03.31.20047621 doi: medRxiv preprint using published single-cell RNA-seq data. We found that ACE2 is mainly expressed in arterial vascular cells in fibrotic lungs, which might be essential for SARS-CoV-2 to enter the bloodstream and to start its circulatory spreading. We observed higher enrichment of ACE2 expression in cardiomyocytes of failed adult human hearts, and higher gene expression of ACE2 in cells infected by the respiratory syncytial virus (RSV) or middle east respiratory syndrome-coronavirus (MERS-CoV). Our findings indicate that patients with pulmonary fibrosis, heart failure, and virus infection have a higher risk and are more susceptible to SARS-CoV-2 infection.
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