Author: CHAO WU; Shufa Zheng; Yu Chen; Min Zheng
Title: Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV, in the nasal tissue Document date: 2020_2_13
ID: dbwfn27p_1
Snippet: Previous studies have investigated the RNA expression of ACE2 in 72 human tissues 4 . They found ACE2 is abundantly present in humans in the epithelia of the lung and small intestines. They also found ACE2 expression in the basal layer of the non-keratinizing squamous epithelium in nasal and oral mucosa and the nasopharynx. Yu Zhao et al. analyzed the single-cell RNA-Seq data of the lung tissues from eight donors and found that ACE2 mainly expres.....
Document: Previous studies have investigated the RNA expression of ACE2 in 72 human tissues 4 . They found ACE2 is abundantly present in humans in the epithelia of the lung and small intestines. They also found ACE2 expression in the basal layer of the non-keratinizing squamous epithelium in nasal and oral mucosa and the nasopharynx. Yu Zhao et al. analyzed the single-cell RNA-Seq data of the lung tissues from eight donors and found that ACE2 mainly expressed in the type II alveolar cells (AT2) 5 . They found that ACE2 shows significantly high expression in AT2 of an Asian donor. However, the abundance of ACE2 expression in the upper respiratory tract needs further identification.
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