Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_11
Snippet: To confirm that oxidative stress is capable of inducing parkin loss, we treated cells with 200 μM hydrogen peroxide and observed a reduction of parkin protein comparable to that found with L-DOPA (39.4 ± 3.8%, p = 0.009 vs. untreated control, N = 3) (Fig. 2D) , in line with a previous report [41] . Altogether, these results indicate that oxidative stress from L-DOPA autoxidation significantly contributes to L-DOPA-induced parkin loss......
Document: To confirm that oxidative stress is capable of inducing parkin loss, we treated cells with 200 μM hydrogen peroxide and observed a reduction of parkin protein comparable to that found with L-DOPA (39.4 ± 3.8%, p = 0.009 vs. untreated control, N = 3) (Fig. 2D) , in line with a previous report [41] . Altogether, these results indicate that oxidative stress from L-DOPA autoxidation significantly contributes to L-DOPA-induced parkin loss.
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