Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_24
Snippet: Phospho-poly-Ub is present in both cytosolic and mitochondrial fractions and leads to mitochondrial parkin translocation Given the importance of phospho-Ub for parkin loss from oxidative stress and mitochondrial depolarization, we next queried where in the cell phospho-Ub is found. As before, we examined high molecular weight phospho-poly-Ub because it is the dominant species of phospho-Ub we observe. Previous work has shown that phospho-poly-Ub .....
Document: Phospho-poly-Ub is present in both cytosolic and mitochondrial fractions and leads to mitochondrial parkin translocation Given the importance of phospho-Ub for parkin loss from oxidative stress and mitochondrial depolarization, we next queried where in the cell phospho-Ub is found. As before, we examined high molecular weight phospho-poly-Ub because it is the dominant species of phospho-Ub we observe. Previous work has shown that phospho-poly-Ub is present in both the cytosol and on mitochondria following PINK1 activation by mitochondrial depolarization [69] .
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