Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_30
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/484857 doi: bioRxiv preprint but inhibition of these pathways did not abrogate parkin loss from L-DOPA treatment (L-DOPA: 41.1 ± 3.5% parkin loss, L-DOPA + bafilomycin A1: 36.6 ± 1.7% parkin loss, p = 0.41, N = 3; L-DOPA: 41.0 ± 5.7% parkin loss, L-DOPA + Z-VAD-FMK: 40.8 ± 4.0% parkin loss, p = 0.98, N = 4) (Fig. S9A,B) . Ta.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/484857 doi: bioRxiv preprint but inhibition of these pathways did not abrogate parkin loss from L-DOPA treatment (L-DOPA: 41.1 ± 3.5% parkin loss, L-DOPA + bafilomycin A1: 36.6 ± 1.7% parkin loss, p = 0.41, N = 3; L-DOPA: 41.0 ± 5.7% parkin loss, L-DOPA + Z-VAD-FMK: 40.8 ± 4.0% parkin loss, p = 0.98, N = 4) (Fig. S9A,B) . Taken together, these data indicate that phospho-Ub-dependent parkin degradation is mediated by the proteasome in the various models tested here.
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