Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_57
Snippet: We also observed that treatments with L-DOPA or CCCP that promoted parkin loss did not cause a loss of mitochondrial proteins consistent with robust induction of mitophagy. These results therefore indicate that mitophagy is not required for phospho-Ub-dependent parkin degradation. This finding is inconsistent with suggestions that parkin degradation downstream of mitochondrial depolarization is linked to mitochondrial elimination [36] [37] [38] [.....
Document: We also observed that treatments with L-DOPA or CCCP that promoted parkin loss did not cause a loss of mitochondrial proteins consistent with robust induction of mitophagy. These results therefore indicate that mitophagy is not required for phospho-Ub-dependent parkin degradation. This finding is inconsistent with suggestions that parkin degradation downstream of mitochondrial depolarization is linked to mitochondrial elimination [36] [37] [38] [39] . Instead, our results indicate that parkin's association with phospho-Ub is the key determinant of its depolarization-and oxidative-stress-induced loss and that this loss can occur independently of mitophagy, in line with a previous study [40] .
Search related documents:
Co phrase search for related documents- mitochondrial protein and parkin degradation: 1
- oxidative stress induce and previous study: 1
- oxidative stress induce and stress induce: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40
- parkin degradation and phospho association: 1, 2, 3, 4, 5, 6
- parkin degradation and phospho ub dependent parkin degradation: 1, 2, 3, 4
- parkin degradation and phospho ub dependent parkin degradation require: 1, 2
- parkin degradation and ub dependent parkin degradation: 1, 2, 3, 4
- parkin loss and phospho association: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- parkin loss and phospho ub dependent parkin degradation: 1, 2, 3, 4
- parkin loss and phospho ub dependent parkin degradation require: 1, 2
- parkin loss and ub dependent parkin degradation: 1, 2, 3, 4
- parkin loss promote and phospho association: 1
- parkin phospho association and phospho association: 1, 2, 3, 4, 5, 6, 7, 8
- parkin phospho association and phospho ub dependent parkin degradation: 1
- parkin phospho association and ub dependent parkin degradation: 1
- phospho association and ub dependent parkin degradation: 1
- phospho ub dependent parkin degradation and ub dependent parkin degradation: 1, 2, 3, 4
- phospho ub dependent parkin degradation require and ub dependent parkin degradation: 1, 2
- previous study and stress induce: 1
Co phrase search for related documents, hyperlinks ordered by date