Selected article for: "RBD ternary complex and ternary complex"

Author: Renhong Yan; Yuanyuan Zhang; Yingying Guo; Lu Xia; Qiang Zhou
Title: Structural basis for the recognition of the 2019-nCoV by human ACE2
  • Document date: 2020_2_20
  • ID: elo7kfun_7
    Snippet: In contrast to the ACE2-B 0 AT1 complex, which has two conformations, "open" and "closed", only the closed state of ACE2 was observed in the dataset for the RBD-ACE2-B 0 AT1 ternary complex. Out of 527,017 selected particles, the overall resolution of the ternary complex was achieved at 2.9 Ã…. However, the resolution for the ACE2-B 0 AT1 complex is substantially higher than that for the RBDs, which are at the peripheral region of the complex (Fi.....
    Document: In contrast to the ACE2-B 0 AT1 complex, which has two conformations, "open" and "closed", only the closed state of ACE2 was observed in the dataset for the RBD-ACE2-B 0 AT1 ternary complex. Out of 527,017 selected particles, the overall resolution of the ternary complex was achieved at 2.9 Ã…. However, the resolution for the ACE2-B 0 AT1 complex is substantially higher than that for the RBDs, which are at the peripheral region of the complex (Fig. 1A) . To improve the local resolutions, focused refinement was applied. Finally, the resolution of the RBDs reached 3.5 Ã…, supporting reliable modelling and interface analysis (Figs. 1, 2; Supplementary Figures S1,S2, Table S1 ).

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