Author: Renhong Yan; Yuanyuan Zhang; Yingying Guo; Lu Xia; Qiang Zhou
Title: Structural basis for the recognition of the 2019-nCoV by human ACE2 Document date: 2020_2_20
ID: elo7kfun_9
Snippet: As expected, each PD accommodates one RBD (Fig. 1B) . The overall interface is similar to that between the SARS-CoV and ACE2 (2, 6), mediated mainly through polar interactions (Fig. 3A ). An extended loop region of RBD spans above the arch-shaped α1 helix of ACE2 like a bridge. The α2 helix and a loop that connects the β3 and β4 antiparallel strands, referred to as Loop 3-4, of the PD also make limited contributions to the coordination of RBD.....
Document: As expected, each PD accommodates one RBD (Fig. 1B) . The overall interface is similar to that between the SARS-CoV and ACE2 (2, 6), mediated mainly through polar interactions (Fig. 3A ). An extended loop region of RBD spans above the arch-shaped α1 helix of ACE2 like a bridge. The α2 helix and a loop that connects the β3 and β4 antiparallel strands, referred to as Loop 3-4, of the PD also make limited contributions to the coordination of RBD.
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