Selected article for: "antiviral target and enzymatic activity"
Author: Dhurvas Chandrasekaran Dinesh; Dominika Chalupska; Jan Silhan; Vaclav Veverka; Evzen Boura
Title: Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein
  • Document date: 2020_4_5
    • ID: ezpjdz55_4
    Snippet: CoV-2 encodes an exonuclease (a second enzymatic activity of the RNA capping factor nsp14) presumably capable of repairing mismatches in newly synthesized double-stranded RNA. Additional antiviral compounds might be necessary to simultaneously target several viral proteins and create a trap that the virus cannot escape by mutation. In any case, drugs targeting proteins other than the RNA polymerase are urgently needed. In this study, we have anal.....
    Document: CoV-2 encodes an exonuclease (a second enzymatic activity of the RNA capping factor nsp14) presumably capable of repairing mismatches in newly synthesized double-stranded RNA. Additional antiviral compounds might be necessary to simultaneously target several viral proteins and create a trap that the virus cannot escape by mutation. In any case, drugs targeting proteins other than the RNA polymerase are urgently needed. In this study, we have analyzed in detail the structure of the N protein NTD (N-NTD) and

    Search related documents:
    Co phrase search for related documents
    • antiviral compound and enzymatic activity: 1, 2
    • antiviral compound and protein target: 1, 2
    • antiviral compound and RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • double strand and protein target: 1
    • double strand and RNA polymerase: 1, 2, 3, 4, 5, 6, 7
    • drug protein target and enzymatic activity: 1
    • drug protein target and protein target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • drug protein target and RNA polymerase: 1, 2, 3, 4
    • enzymatic activity and protein target: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • enzymatic activity and RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • mutation escape and protein target: 1, 2, 3
    • mutation escape and RNA polymerase: 1, 2
    • protein target and RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • RNA polymerase and urgently need: 1