Selected article for: "infectious disease and patient report"
Author: Lee, Seung Hun; Shin, Na-Ri; Kim, Choon-Mee; Park, Sungdo; Yun, Na Ra; Kim, Dong-Min; Jung, Dong Sik
Title: First identification of Anaplasma phagocytophilum in both a biting tick Ixodes nipponensis and a patient in Korea: a case report
  • Cord-id: z0bbz19b
  • Document date: 2020_11_11
    • ID: z0bbz19b
    Snippet: BACKGROUND: Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by Anaplasma phagocytophilum. To date, there have been no reported cases of A. phagocytophilum infection found in both the biting tick and the patient following a tick bite. CASE PRESENTATION: An 81-year-old woman presented with fever following a tick bite, with the tick still intact on her body. The patient was diagnosed with HGA. The tick was identified as Ixodes nipponensis by morphological and molecul
    Document: BACKGROUND: Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by Anaplasma phagocytophilum. To date, there have been no reported cases of A. phagocytophilum infection found in both the biting tick and the patient following a tick bite. CASE PRESENTATION: An 81-year-old woman presented with fever following a tick bite, with the tick still intact on her body. The patient was diagnosed with HGA. The tick was identified as Ixodes nipponensis by morphological and molecular biological detection methods targeting the 16S rRNA gene. The patient’s blood was cultured after inoculation into the human promyelocytic leukemia cell line HL-60. A. phagocytophilum growth was confirmed via culture and isolation. A. phagocytophilum was identified in both the tick and the patient’s blood by Anaplasma-specific groEL- and ankA-based nested polymerase chain reaction followed by sequencing. Moreover, a four-fold elevation in antibodies was observed in the patient’s blood. CONCLUSION: We report a case of a patient diagnosed with HGA following admission for fever due to a tick bite. A. phagocytophilum was identified in both the tick and the patient, and A. phagocytophilum was successfully cultured. The present study suggests the need to investigate the possible incrimination of I. nipponensis as a vector for HGA in Korea. SUPPLEMENTARY INFORMATION: Supplementary information accompanies this paper at 10.1186/s12879-020-05522-5.

    Search related documents:
    Co phrase search for related documents
    • abdominal pain and admission prior: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • abdominal pain and admission time: 1, 2, 3, 4, 5, 6, 7
    • abdominal pain and admission time negative: 1
    • abdominal pain and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • abdominal pain and liver function test: 1
    • accordingly discharge and admission prior: 1
    • acutely ill and admission prior: 1
    • acutely ill and admission time: 1
    • additional study and admission prior: 1
    • additional study and admission time: 1, 2, 3
    • admission prior and liver function: 1, 2, 3, 4, 5, 6, 7
    • admission time and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21