Author: Benussi, A.; Pilotto, A.; Premi, E.; Libri, I.; Giunta, M.; Agosti, C.; Alberici, A.; Baldelli, E.; Benini, M.; Bonacina, S.; Brambilla, L.; Caratozzolo, S.; Cortinovis, M.; Costa, A.; Cotti Piccinelli, S.; Cottini, E.; Cristillo, V.; Delrio, I.; Filosto, M.; Gamba, M.; Gazzina, S.; Gilberti, N.; Gipponi, S.; Imarisio, A.; Invernizzi, P.; Leggio, U.; Leonardi, M.; Liberini, P.; Locatelli, M.; Masciocchi, S.; Poli, L.; Rao, R.; Risi, B.; Rozzini, L.; Scalvini, A.; Schiano di Cola, F.; Spezi, R.; Vergani, V.; Volonghi, I.; Zoppi, N.; Borroni, B.; Magoni, M.; Pezzini, A.; Padovani, A.
Title: Clinical features and outcomes of inpatients with neurological disease and COVID-19 Cord-id: zgix8quw Document date: 2020_5_2
ID: zgix8quw
Snippet: Objective: To report the clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurological diseases with COVID-19 in a Neuro-COVID unit compared to patients without COVID-19. Methods: In this retrospective, single centre cohort study, we included all adult inpatients with confirmed COVID-19, who had been discharged or died by April 5, 2020. Demographic, clinical, treatment, and laboratory data were extracted from medical records. Results: 1
Document: Objective: To report the clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurological diseases with COVID-19 in a Neuro-COVID unit compared to patients without COVID-19. Methods: In this retrospective, single centre cohort study, we included all adult inpatients with confirmed COVID-19, who had been discharged or died by April 5, 2020. Demographic, clinical, treatment, and laboratory data were extracted from medical records. Results: 173 patients were included in this study, of whom 56 resulted positive for COVID-19 and 117 resulted negative for COVID-19. Patients with COVID-19 were older, had a different distribution regarding admission diagnoses, including cerebrovascular disorders, and had a higher quick Sequential Organ Failure Assessment (qSOFA) score on admission (all p<0.05). In-hospital mortality rates and incident delirium were significantly higher in the COVID-19 group (all p<0.05). COVID-19 and non-COVID patients with stroke had similar baseline characteristics but patients with COVID-19 had higher modified Rankin scale scores at discharge (p<0.0001), with a significantly lower number of patients with a good outcome (p<0.0001). Multivariable regressions showed increasing odds of in-hospital death associated with higher qSOFA scores (odds ratio 4.47, 95% CI 1.21-16.5; p=0.025), lower platelet count (0.98, 0.97-0.99; p=0.005) and higher lactate dehydrogenase (1.01, 1.00-1.03; p=0.009) on admission. Conclusions: COVID-19 patients admitted with neurological disease, including stroke, have a significantly higher in-hospital mortality, incident delirium and higher disability than patients without COVID-19.
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