Author: Jamie A. Kelly; Jonathan D. Dinman
Title: Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2 Document date: 2020_3_15
ID: 62izhj8d_4
Snippet: The -1 PRF signal can be broken down into three discrete parts: the "slippery site", a linker region, and a downstream stimulatory region of mRNA secondary structure, typically an mRNA suggesting that it may present a target for small molecule therapeutics (7, 8) . In addition, the presence of a hairpin located immediately 5' of the slippery site has been reported to regulate -1 PRF by attenuating its activity (14) . Here, we report on the -1 PRF.....
Document: The -1 PRF signal can be broken down into three discrete parts: the "slippery site", a linker region, and a downstream stimulatory region of mRNA secondary structure, typically an mRNA suggesting that it may present a target for small molecule therapeutics (7, 8) . In addition, the presence of a hairpin located immediately 5' of the slippery site has been reported to regulate -1 PRF by attenuating its activity (14) . Here, we report on the -1 PRF signal from SARS-CoV2.
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