Author: Wanchao Yin; Chunyou Mao; Xiaodong Luan; Dan-Dan Shen; Qingya Shen; Haixia Su; Xiaoxi Wang; Fulai Zhou; Wenfeng Zhao; Minqi Gao; Shenghai Chang; Yuan-Chao Xie; Guanghui Tian; He-Wei Jiang; Sheng-Ce Tao; Jingshan Shen; Yi Jiang; Hualiang Jiang; Yechun Xu; Shuyang Zhang; Yan Zhang; H. Eric Xu
Title: Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir Document date: 2020_4_9
ID: 7v7pzclb_31
Snippet: The model of the SARS-CoV RdRp (PDB code: 6NUR) was used as the start for model rebuilding against SARS-CoV-2 RdRp apo structure and RdRp-RNA-Remdesivir complex structure. The model was docked in the using Chimera(41) , followed by iterative manual adjustment in COOT(42), real space refinement using real_space_refine in PHENIX(43). The model statistics was validated using MolProbity. Structural figures were prepared in Chimera and PyMOL (https://.....
Document: The model of the SARS-CoV RdRp (PDB code: 6NUR) was used as the start for model rebuilding against SARS-CoV-2 RdRp apo structure and RdRp-RNA-Remdesivir complex structure. The model was docked in the using Chimera(41) , followed by iterative manual adjustment in COOT(42), real space refinement using real_space_refine in PHENIX(43). The model statistics was validated using MolProbity. Structural figures were prepared in Chimera and PyMOL (https://pymol.org/2/). The final refinement statistics are provided in Table S1 .
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