Potential use of Citrus essential oils against acute respiratory syndrome caused by coronavirus

Arena, Mario Eduardo Alberto María Rosa Cartagena Elena

The treatments being investigated for the pandemic associated with a severe acute respiratory syndrome caused by the new coronavirus (SARS-CoV2) aim to inhibit viral replication or inhibit enzymatic elastase in the lung, responsible for the SARS-CoV cell entry mechanism and the pathogenesis of severe pneumonia caused by infection. There is also a need to improve alveolar surfactant capacity and inhibition of the exacerbated inflammatory response. Current knowledge allows us to infer that Citrus essential oils could be considered an individual or a complementary highly valuable alternative for the viral infection caused by SARS-CoV due to its antiviral activity, particularly against coronavirus, anti-elastase, anti-inflammatory, antibacterial and antibiofilm properties. Furthermore, its proven capacity of biosurfactants, antioxidants, and pain inhibitors would help to treat acute respiratory syndrome. This review aims to encourage the development of more detailed studies on Citrus essential oils as a new multi-objective strategy to treat SARS-CoV2 infection. Abbreviations: SARS-CoV: Severe Acute Respiratory Syndrome Coronavirus;GRAS: Generally Recognized as Safe;TRP: Transient Receptor Proteins;HeLa-CEACAM1a: HeLa-epithelial carcinoembryonic antigen-related cell adhesion molecule 1a;HSV: Herpes Simplex Virus;FDA: Food and Drug Administration;ANMAT: National Administration of Medicines, Food and Medical Technology, Argentina;AFSSAPS: Agence Française de Sécurité Sanitaire des Produits de Santé, France;ACE2:Angiotensin-converting enzyme-2 [ABSTRACT FROM AUTHOR] Copyright of Journal of Essential Oil Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)