Author: Anamika Basu; Anasua Sarkar; Ujjwal Maulik
Title: Strategies for vaccine design for corona virus using Immunoinformatics techniques Document date: 2020_3_2
ID: 618glydc_3
Snippet: According to Lu et al, 2020 [1] , genome sequence of 2019-nCoV is closely related (with 88% identity) to two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21 and genetically distinct from SARS-CoV. Two complete virus genomes (HKU-SZ-002a and HKU-SZ-005b) are sequenced from 2019-nCoV infected patients [2] . HKU-SZ-002a and HKU-SZ-005b differ from each other by only two bases. One of them i.....
Document: According to Lu et al, 2020 [1] , genome sequence of 2019-nCoV is closely related (with 88% identity) to two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21 and genetically distinct from SARS-CoV. Two complete virus genomes (HKU-SZ-002a and HKU-SZ-005b) are sequenced from 2019-nCoV infected patients [2] . HKU-SZ-002a and HKU-SZ-005b differ from each other by only two bases. One of them is a non-synonymous mutation at amino acid position 336 of non-structural protein 4 (Ser336 for HKU-SZ-002a; Leu336 for HKU-SZ-005b). The amino acid sequence of the N-terminal domain of Spike subunit 1 of this novel coronavirus is around 66% identical to those of the SARS-related coronaviruses, and the core domain of the receptor binding domain of this novel coronavirus has about 68% amino acid identity with those of the SARS-related coronavirus. But the protein sequence of the external subdomain region of receptor binding domain of Spike subunit 1 has only 39% identity, which might affect the choice of human receptor and therefore the biological activity of this virus.
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