Strategies for vaccine design for corona virus using Immunoinformatics techniques

Anamika Basu; Anasua Sarkar; Ujjwal Maulik

At present in China and whole world, considering the emergency situation due to corona virus infection, rapid development in vaccine design is the most argent step to prevent pandemics. Because by using vaccine the mortality rate due to coronavirus can be controlled. This technique is applied successfully for smallpox virus, polio virus etc. Though for some other common viruses such as dengue virus, hepatitis C virus, human immunodeficiency virus and coronavirus, vaccine has not been invented till now. Due to lack of definite information about growth, replication and pathogenesis of these viruses. Therefore, computational techniques are used for epitope mapping, which is the preliminary step for vaccine design to prevent coronavirus infection. This study integrates several immunoinformatics and molecular docking methods to recognize potential epitopes of non-structural protein NS4 in coronavirus.