Author: Anamika Basu; Anasua Sarkar; Ujjwal Maulik
Title: Strategies for vaccine design for corona virus using Immunoinformatics techniques Document date: 2020_3_2
ID: 618glydc_44
Snippet: Likewise, presence of wider peptide binding groove in MHC II molecule than that of MHC I, 15 mer epitopes are investigated by smm/nn/sturnilo method along with their IC 50 values and are listed in Table 3 . For MHC II binding prediction method, a 15 mer T cell epitope sequence 76 PTDTYTSVYLGKFRG 90 of non-structural protein 4, displays a percentile rank 22.0 with IC 50 value 22.0 at the time of interaction with HLA-DRB5*01:01MHC II allele. This r.....
Document: Likewise, presence of wider peptide binding groove in MHC II molecule than that of MHC I, 15 mer epitopes are investigated by smm/nn/sturnilo method along with their IC 50 values and are listed in Table 3 . For MHC II binding prediction method, a 15 mer T cell epitope sequence 76 PTDTYTSVYLGKFRG 90 of non-structural protein 4, displays a percentile rank 22.0 with IC 50 value 22.0 at the time of interaction with HLA-DRB5*01:01MHC II allele. This result approves that this peptide can be selected as T cell epitope with MHC II restriction for our protein of interest. Moreover, this T cell epitope sequence is well conserved among the nonstructural protein 4 present in different corona viruses.
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