Author: Tamina Park; Sang-Yeop Lee; Seil Kim; Mi Jeong Kim; Hong Gi Kim; Sangmi Jun; Seung Il Kim; Bum Tae Kim; Edmond Changkyun Park; Daeui Park
Title: Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2 Document date: 2020_2_27
ID: dqxfcwyu_3
Snippet: After the severe epidemic events of SARS and MERS, researchers have been made great efforts to 80 discover neutralizing antibodies for CoVs [17, 18] . The neutralizing antibodies for CoVs mainly targeted to S-81 RBD. S protein of SARS-CoV-2 shows 76.2% and 34.1% amino acid sequence identity to those of SARS-CoV 82 and MERS-CoV, respectively. Therefore, the neutralizing antibodies of SARS-CoV and MERS-CoV S proteins 83 may have a possibility to in.....
Document: After the severe epidemic events of SARS and MERS, researchers have been made great efforts to 80 discover neutralizing antibodies for CoVs [17, 18] . The neutralizing antibodies for CoVs mainly targeted to S-81 RBD. S protein of SARS-CoV-2 shows 76.2% and 34.1% amino acid sequence identity to those of SARS-CoV 82 and MERS-CoV, respectively. Therefore, the neutralizing antibodies of SARS-CoV and MERS-CoV S proteins 83 may have a possibility to interact with SARS-CoV-2 S protein and show similar viral neutralization effect. In the 84 present study, we employed a antibody-antigen docking approach to predict the interaction between SARS-CoV-85 2 S-RBD and previously reported neutralization antibodies for SARS-CoV and MERS-CoV.
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