Selected article for: "action mechanism and systemic administration"

Author: Karnina, Resiana; Arif, Syafri Kamsul; Hatta, Mochammad; Bukhari, Agussalim
Title: Molecular mechanisms of lidocaine
  • Cord-id: w03yis5n
  • Document date: 2021_8_17
  • ID: w03yis5n
    Snippet: Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can be independent of its primary mechanism of action, sodium channel inhibition. Here we review the pathophysiological underpinnings of lidocaine's r
    Document: Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can be independent of its primary mechanism of action, sodium channel inhibition. Here we review the pathophysiological underpinnings of lidocaine's role as an anti-nociceptive, anti-inflammatory mediated by toll-like receptor (TLR) and nuclear factor kappa-β (NF-kβ) signalling pathways and downstream cytokine effectors high mobility group box 1 (HMGB1) and tumour necrosis factor-α (TNF-α).

    Search related documents:
    Co phrase search for related documents
    • abdominal surgery and administer kg: 1
    • abdominal surgery and liver injury: 1, 2
    • abdominal surgery and local anesthesia: 1, 2, 3
    • abdominal surgery and local anesthetic: 1, 2
    • abdominal surgery and low concentration: 1
    • abdominal surgery and lung injury: 1, 2, 3
    • acetylcholine nicotinic and action potential: 1
    • acetylcholine nicotinic and activation protein: 1
    • acetylcholine nicotinic and acute lung injury: 1, 2, 3, 4, 5
    • acetylcholine nicotinic and lung injury: 1, 2, 3, 4, 5
    • acetylcholine nicotinic receptor and activation protein: 1
    • acetylcholine nicotinic receptor and acute lung injury: 1, 2, 3, 4, 5