Author: Jamie A. Kelly; Jonathan D. Dinman
Title: Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2 Document date: 2020_3_15
ID: 62izhj8d_10
Snippet: The structure of the SARS-CoV -1 PRF signal was previously determined to include a threestemmed mRNA pseudoknot (11) . Using this as a guide, the single C to A base difference between the core SARS-CoV and SARS-CoV-2 -1 PRF signals maps to a loop that is not predicted to alter the structure of the -1 PRF stimulating element (7) (Fig. 1C) . In contrast, the attenuator hairpin contains six differences in the nucleotide sequence between the two viru.....
Document: The structure of the SARS-CoV -1 PRF signal was previously determined to include a threestemmed mRNA pseudoknot (11) . Using this as a guide, the single C to A base difference between the core SARS-CoV and SARS-CoV-2 -1 PRF signals maps to a loop that is not predicted to alter the structure of the -1 PRF stimulating element (7) (Fig. 1C) . In contrast, the attenuator hairpin contains six differences in the nucleotide sequence between the two viruses, and the SARS-CoV-2 element is predicted to be less stable than its SARS-CoV counterpart (Fig. 1D) . This suggests that the attenuation activity of this element is not as important as the ability to direct -1 PRF per se.
Search related documents:
Co phrase search for related documents- attenuation activity and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- attenuator hairpin and PRF signal: 1, 2, 3
- attenuator hairpin and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- attenuator hairpin and SARS CoV structure: 1
- attenuator hairpin and SARS element: 1
- base difference and SARS cov: 1
- nucleotide sequence and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- nucleotide sequence and SARS CoV structure: 1, 2, 3, 4
- nucleotide sequence and SARS element: 1
- nucleotide sequence and virus nucleotide sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- prf direct and SARS cov: 1, 2, 3, 4
- prf direct and SARS element: 1
- PRF signal and SARS cov: 1, 2, 3, 4, 5, 6, 7
- SARS cov and virus nucleotide sequence: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date