Author: Lu, Ligong; Zhang, Hui; Dauphars, Danielle J.; He, You-Wen
Title: A Potential Role of Interleukin-10 in COVID-19 Pathogenesis Cord-id: w59zlxmy Document date: 2020_11_2
ID: w59zlxmy
Snippet: A unique feature of the cytokine storm in COVID-19 is the dramatic elevation of IL-10. Its significance was thought as a negative-feedback mechanism for suppressing inflammation. However, several lines of clinical evidence suggest that dramatic early pro-inflammatory IL-10 elevation might play a pathological role in COVID-19 severity.
Document: A unique feature of the cytokine storm in COVID-19 is the dramatic elevation of IL-10. Its significance was thought as a negative-feedback mechanism for suppressing inflammation. However, several lines of clinical evidence suggest that dramatic early pro-inflammatory IL-10 elevation might play a pathological role in COVID-19 severity.
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