Selected article for: "activity addition and acute respiratory distress syndrome"
Author: AJ Venkatakrishnan; Arjun Puranik; Akash Anand; David Zemmour; Xiang Yao; Xiaoying Wu; Ramakrishna Chilaka; Dariusz K Murakowski; Kristopher Standish; Bharathwaj Raghunathan; Tyler Wagner; Enrique Garcia-Rivera; Hugo Solomon; Abhinav Garg; Rakesh Barve; Anuli Anyanwu-Ofili; Najat Khan; Venky Soundararajan
Title: Knowledge synthesis from 100 million biomedical documents augments the deep expression profiling of coronavirus receptors
  • Document date: 2020_3_29
    • ID: j7t9nebs_1
    Snippet: Since December 2019, the SARS-CoV-2 virus has been rapidly spreading across the globe. The associated disease has been declared a pandemic by the World Health Organization (WHO), with over 350,000 confirmed cases and 15,000 deaths across nearly every country as of March 23, 2020 1 . The constellation of symptoms, ranging from acute respiratory distress syndrome (ARDS) to gastrointestinal issues, is similar to that observed in the 2002 Severe Acut.....
    Document: Since December 2019, the SARS-CoV-2 virus has been rapidly spreading across the globe. The associated disease has been declared a pandemic by the World Health Organization (WHO), with over 350,000 confirmed cases and 15,000 deaths across nearly every country as of March 23, 2020 1 . The constellation of symptoms, ranging from acute respiratory distress syndrome (ARDS) to gastrointestinal issues, is similar to that observed in the 2002 Severe Acute Respiratory Syndrome (SARS) epidemic and the 2012 Middle East respiratory syndrome (MERS) outbreak. SARS, MERS, and COVID-19 are all caused by Coronaviruses (CoV), deriving their name from the crown-like spike proteins protruding from the viral capsid surface. Coronavirus infection is driven by the attachment of the viral spike protein to specific human cell-surface receptors: ACE2 for SARS-CoV-2 and SARS-CoV 2-4 , DPP4 for MERS-CoV 5 and ANPEP for specific É‘-coronaviruses 6 . In addition to these receptors, the protease activity of TMPRSS2 has also been implicated in viral entry 7, 8 .

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