Selected article for: "Codon usage and dinucleotide usage"
Author: Jacob Kames; David Dillon Holcomb; Ofer Kimchi; Michael DiCuccio; Nobuko Hamasaki-Katagiri; Tony Wang; Anton A Komar; Aikaterini Alexaki; Chava Kimchi-Sarfaty
Title: Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
  • Document date: 2020_3_31
    • ID: 2fn25l6m_19
    Snippet: We performed a comprehensive characterization of the codon, codon pair and dinucleotide usage of the SARS-CoV-2 genome with the intention to identify the best targets for codon pair deoptimization in order to design an attenuated virus for vaccine development. Genes N and S were singled out as the best potential targets for deoptimization, due to the relatively high CPB among the viral genes. The copyright holder for this preprint (which was not .....
    Document: We performed a comprehensive characterization of the codon, codon pair and dinucleotide usage of the SARS-CoV-2 genome with the intention to identify the best targets for codon pair deoptimization in order to design an attenuated virus for vaccine development. Genes N and S were singled out as the best potential targets for deoptimization, due to the relatively high CPB among the viral genes. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.30.016832 doi: bioRxiv preprint Furthermore, they are structural proteins with known functions. Therefore, it will be possible to study the results of codon pair deoptimization on the fitness of the virus.

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