Selected article for: "HCoV infection and MERS cov"
Author: Zhao, Zhenyu; Lu, Kefeng; Mao, Binli; Liu, Shi; Trilling, Mirko; Huang, Ailong; Lu, Mengji; Lin, Yong
Title: The interplay between emerging human coronavirus infections and autophagy
  • Cord-id: wh1espy8
  • Document date: 2021_2_3
    • ID: wh1espy8
    Snippet: Following outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2002 and 2012, respectively, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic emerging human coronavirus (hCoV). SARS-CoV-2 is currently causing the global coronavirus disease 2019 (COVID-19) pandemic. CoV infections in target cells may stimulate the formation of numerous double-membrane autophagosomes an
    Document: Following outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2002 and 2012, respectively, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic emerging human coronavirus (hCoV). SARS-CoV-2 is currently causing the global coronavirus disease 2019 (COVID-19) pandemic. CoV infections in target cells may stimulate the formation of numerous double-membrane autophagosomes and induce autophagy. Several studies provided evidence that hCoV infections are closely related to various cellular aspects associated with autophagy. Autophagy may even promote hCoV infection and replication. However, so far it is unclear how hCoV infections induce autophagy and whether the autophagic machinery is necessary for viral propagation. Here, we summarize the most recent advances concerning the mutual interplay between the autophagic machinery and the three emerging hCoVs, SARS-CoV, MERS-CoV, and SARS-CoV-2 and the model system mouse hepatitis virus. We also discuss the applicability of approved and well-tolerated drugs targeting autophagy as a potential treatment against COVID-19.

    Search related documents:
    Co phrase search for related documents
    • accessory protein and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • accessory protein and lysosomal damage: 1
    • accessory protein and lysosomal degradation: 1, 2
    • accessory protein structural protein and acute sars cov respiratory syndrome coronavirus: 1, 2
    • accumulate evidence and adaptive immune response: 1
    • activate kinase and acute sars cov respiratory syndrome coronavirus: 1
    • acute sars cov respiratory syndrome coronavirus and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute sars cov respiratory syndrome coronavirus and adaptive immune response innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • acute sars cov respiratory syndrome coronavirus and lysosomal damage: 1
    • acute sars cov respiratory syndrome coronavirus and lysosomal degradation: 1, 2, 3, 4, 5, 6
    • adaptive immune response and lysosomal degradation: 1
    • adaptive immune response innate and lysosomal degradation: 1