Author: Mushtaq Hussain; Nusrat Jabeen; Anusha Amanullah; Ayesha Ashraf Baig; Basma Aziz; Sanya Shabbir; Fozia Raza
Title: Structural Basis of SARS-CoV-2 Spike Protein Priming by TMPRSS2 Document date: 2020_4_22
ID: 34ljq0qt_15
Snippet: The entry of the SARS-CoV-2 in the host cell is driven by the proteolytic cleavage of its spike protein resulting in the formation of two fragments, S1/S2 and S2' (Hoffman et al., 2020) . The precise positioning of the proteolytic cleavage sites have been mapped by sequence comparison and found to be at the junction of Arg685/Ser686 and Arg815/Ser816. The cleavage at the later site results in the production of S1/S2 and S2' fragments, which is ne.....
Document: The entry of the SARS-CoV-2 in the host cell is driven by the proteolytic cleavage of its spike protein resulting in the formation of two fragments, S1/S2 and S2' (Hoffman et al., 2020) . The precise positioning of the proteolytic cleavage sites have been mapped by sequence comparison and found to be at the junction of Arg685/Ser686 and Arg815/Ser816. The cleavage at the later site results in the production of S1/S2 and S2' fragments, which is necessary for the viral entry author/funder. All rights reserved. No reuse allowed without permission.
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