Author: Protti, Alessandro; Meessen, Jennifer; Bottazzi, Barbara; Garlanda, Cecilia; Milani, Angelo; Bacci, Monica; Mantovani, Alberto; Cecconi, Maurizio; Latini, Roberto; Caironi, Pietro
Title: Circulating pentraxin 3 in severe COVIDâ€19 or other pulmonary sepsis Cord-id: wx99br10 Document date: 2021_3_13
ID: wx99br10
Snippet: The long pentraxin 3 (PTX3), described initially as a microvascular inflammation marker, is an acute-phase protein released by several cell types in response to infection or tissue damage. It contributes to resistance to bacteria, fungi, viruses, and inflammation regulation (1). Circulating PTX3 was abnormally high (>2 ng/ml) in all 958 patients with severe sepsis or septic shock included in a pre-planned sub-study of the Albumin Italian Outcome Sepsis (ALBIOS) trial (2).
Document: The long pentraxin 3 (PTX3), described initially as a microvascular inflammation marker, is an acute-phase protein released by several cell types in response to infection or tissue damage. It contributes to resistance to bacteria, fungi, viruses, and inflammation regulation (1). Circulating PTX3 was abnormally high (>2 ng/ml) in all 958 patients with severe sepsis or septic shock included in a pre-planned sub-study of the Albumin Italian Outcome Sepsis (ALBIOS) trial (2).
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