Author: Sandra De Meyer; Denisa Bojkova; Jindrich Cinati; Ellen Van Damme; Christophe Buyck; Marnix Van Loock; Brian Woodfall; Sandra Ciesek
Title: Lack of Antiviral Activity of Darunavir against SARS-CoV-2 Document date: 2020_4_8
ID: 679qfp2s_2
Snippet: As no specific antivirals for treatment of COVID-19 are available, one avenue of clinical interest is the use of human immunodeficiency virus (HIV) protease inhibitors (PIs) as a therapeutic intervention. The potential for HIV PIs as a treatment for COVID-19 is mainly based on limited virologic and clinical data on the HIV protease inhibitor lopinavir with low-dose ritonavir (as a pharmacoenhancer; LPV/r) in patients infected with severe acute re.....
Document: As no specific antivirals for treatment of COVID-19 are available, one avenue of clinical interest is the use of human immunodeficiency virus (HIV) protease inhibitors (PIs) as a therapeutic intervention. The potential for HIV PIs as a treatment for COVID-19 is mainly based on limited virologic and clinical data on the HIV protease inhibitor lopinavir with low-dose ritonavir (as a pharmacoenhancer; LPV/r) in patients infected with severe acute respiratory syndrome related to a coronavirus (SARS-CoV) (4) . After demonstrating the in vitro antiviral activity of LPV against SARS-CoV-1, the clinical response of patients with SARS to a combination of LPV/r and ribavirin was examined. Patients treated with LPV/r had lower rates of adverse clinical outcomes at day 21 following the onset of symptoms compared with historical controls (4). However, recent data in hospitalized adults with severe confirmed COVID-19 treated with LPV/r in addition to a standard care of ventilation, oxygen, vasopressor support, antibiotics and renalreplacement therapy showed that there was no significant improvement in time to clinical improvement or mortality at day 28 compared with the standard care (5).
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