Author: Valpione, Sara; Mundra, Piyushkumar A; Galvani, Elena; Campana, Luca G; Lorigan, Paul; De Rosa, Francesco; Gupta, Avinash; Weightman, John; Mills, Sarah; Dhomen, Nathalie; Marais, Richard
Title: The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival. Cord-id: xnlrv3e1 Document date: 2021_7_2
ID: xnlrv3e1
Snippet: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic
Document: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
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