Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients

Yi Han; Haidong Zhang; Sucheng Mu; Wei Wei; Chaoyuan Jin; Yuan Xue; Chaoyang Tong; Yunfei Zha; Zhenju Song; Guorong Gu

A trained team of physicians and medical students reviewed and collected demographic, epidemiological, clinical, physical examination findings, and laboratory data from electronic medical records. Laboratory assessments consisted of complete blood count, liver and renal function, markers of cardiac injury, measures of electrolytes, C-reactive protein and procalcitonin, and assessment of coagulation and lactate dehydrogenase, among other parameters. We defined the degree of severity of COVID-19 patients (severe vs. non-severe) at the time of admission, according to American Thoracic Society (ATS) guidelines for CAP(27). If imaging scans were available, the radiologic assessments of chest computed tomography (CT) were reviewed and scored by an attending radiologist who extracted the data. The APACHE II and SOFA score were calculated basen on clinical and experimental data on admission, and CT score was calculated based on a semiquantitative scoring system (Supplement Table 1 ).