Author: Brian G. Pierce; Zhen-Yong Keck; Ruixue Wang; Patrick Lau; Kyle Garagusi; Khadija Elkholy; Eric A. Toth; Richard A. Urbanowicz; Johnathan D. Guest; Pragati Agnihotri; Melissa C. Kerzic; Alexander Marin; Alexander K. Andrianov; Jonathan K. Ball; Roy A. Mariuzza; Thomas R. Fuerst; Steven K.H. Foung
Title: Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization Document date: 2020_4_17
ID: b6to1v4u_71
Snippet: Infection by HCVpp was measured in the presence of anti-E2 MAbs, tested animal sera, preimmune animal sera, and non-specific IgG at the same dilution. Each sample was tested in duplicate or triplicate. Neutralizing activities were reported as 50% inhibitory dilution (ID50) values and were calculated by nonlinear curve fitting (GraphPad Prism), using lower and upper bounds (0% and 100% inhibition) as constraints to assist curve fitting......
Document: Infection by HCVpp was measured in the presence of anti-E2 MAbs, tested animal sera, preimmune animal sera, and non-specific IgG at the same dilution. Each sample was tested in duplicate or triplicate. Neutralizing activities were reported as 50% inhibitory dilution (ID50) values and were calculated by nonlinear curve fitting (GraphPad Prism), using lower and upper bounds (0% and 100% inhibition) as constraints to assist curve fitting.
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