Author: Julien Riou; Anthony Hauser; Michel J Counotte; Christian L Althaus
Title: Adjusted age-specific case fatality ratio during the COVID-19 epidemic in Hubei, China, January and February 2020 Document date: 2020_3_6
ID: mrsya6wz_32
Snippet: Third, the proportion of asymptomatic infections is uncertain. Detection of asymptomatic SARS-CoV-2 infection is limited by the focus of testing on symptomatic patients seeking care. Two independent studies have obtained similar estimates using different data sources. During the outbreak on the cruise ship "Diamond Princess", nearly all individuals were tested regardless of symptoms, leading to an average proportion of symptomatic infections of 8.....
Document: Third, the proportion of asymptomatic infections is uncertain. Detection of asymptomatic SARS-CoV-2 infection is limited by the focus of testing on symptomatic patients seeking care. Two independent studies have obtained similar estimates using different data sources. During the outbreak on the cruise ship "Diamond Princess", nearly all individuals were tested regardless of symptoms, leading to an average proportion of symptomatic infections of 82.1% (95%CrI: 79.8-84.5) of infected people develop symptoms and become infectious [19] . Another study of 87 contacts of infected cases in Shenzhen, China, estimated that 80.4% (95%CrI: 70.9-87.4) were symptomatic [18] . Additionally, dichotomization into asymptomatic and symptomatic is a simplification; SARS-CoV-2 causes a spectrum of symptoms, likely depending on age, sex and comorbidities. Serological surveys will be needed to better characterize asymptomatic infections [25] .
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