Selected article for: "cohort study and MERS cov"
Author: Mingzhu Yin; Lijuan Zhang; Guangtong Deng; Chaofei Han; Minxue Shen; Hongyin Sun; Furong Zeng; Wei Zhang; Lan Chen; Qingqing Luo; Dujuan Yao; Min Wu; Shihuan Yu; Hui Chen; David Baud; Xiang Chen
Title: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Pregnancy In China: A Retrospective Cohort Study
  • Document date: 2020_4_11
    • ID: 6wolrfvk_33
    Snippet: Coronaviruses such as SARS-CoV and MERS-CoV, can cause severe adverse pregnancy outcomes, including miscarriage, intrauterine growth restriction, premature delivery, neonatal asphyxia and maternal death. 15, [24] [25] [26] However, the effects of SARS-CoV-2 infection on pregnancy is unclear, and so far there is no evidence of severity for mothers and newborns. Therefore, a cohort study is necessary and urgent to provide a reliable guideline for m.....
    Document: Coronaviruses such as SARS-CoV and MERS-CoV, can cause severe adverse pregnancy outcomes, including miscarriage, intrauterine growth restriction, premature delivery, neonatal asphyxia and maternal death. 15, [24] [25] [26] However, the effects of SARS-CoV-2 infection on pregnancy is unclear, and so far there is no evidence of severity for mothers and newborns. Therefore, a cohort study is necessary and urgent to provide a reliable guideline for management of pregnant women with SARS-CoV-2 infection. To this end, we reported a cohort analysis of clinical outcomes in 31 pregnant women and 35 non-pregnant women with laboratory confirmed COVID-19. To our knowledge, this is the first cohort study that has been reported to date. Previously, a descriptive study demonstrated that the clinical characteristics of pregnant patients with COVID-19 resembled those of non-pregnant patients with COVID-19. 12 However, we found a shorter interval from onset to hospitalization and severer COVID-19 in pregnant patients than non-pregnant patients with SARS-CoV-2 infection. This phenomenon could be partly explained by the special states of immune suppression and physiological adaptive changes during pregnancy. Infectious pneumonia is an essential cause of morbidity and mortality in pregnant women. For example, H1N1 virus caused a higher rate of hospital admission and an increasing risk for pregnancy complications in pregnant women than the general population. 27 In our study, despite no death in pregnant women and neonates, our finding suggested that more attention should be paid to the pregnant women especially to those who had a history of exposure to the All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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