Strategies for vaccine design for corona virus using Immunoinformatics techniques

Anamika Basu; Anasua Sarkar; Ujjwal Maulik

For MHC I binding prediction scores, the peptide with the lowest percentile rank and IC 50 value, is selected for their highest affinity for that interacting MHC I allele. The T cell epitope 76 PTDTYTSVY 84 is considered on the basis of its interaction with large number of alleles and lowest IC 50 value with HLA-A*01:01 MHC I allele. For this epitope, MHC I processing score with that specific allele comprises proteasome score 1.25, TAP score 1.02, MHC IC 50 value is 6.7 nm. This means that this specific epitope has high affinity to MHC I molecule during antigen presentation. Moreover that, this epitope when interacting with selective MHC I allele shows the highest population coverage not only for Chinese population, but also has higher population coverage compared to other epitopes, for Indian and whole world population. Henceforth, this epitope is considered as epitope of choice for CD8 + T cells.