Strategies for vaccine design for corona virus using Immunoinformatics techniques

Anamika Basu; Anasua Sarkar; Ujjwal Maulik

Though in general most peptide-based vaccines are developed considering B cell epitopes, in our present study both B cell and T cell epitopes, present in non-structural protein 4, are considered for vaccine design against coronavirus. These two T cell epitopes can stimulate immunogenic response after administration inside the human body. This immunological reaction can prevent coronavirus infection in human as well as rat and murine, when they come in contact with this virus in future. Since these epitopes are well restricted with MHC molecules and at the same time, they are almost conserved among other homologous proteins. These proteins include non-structural protein 4, obtained from novel-coronavirus infected patient in China. Thus, these epitopes can be proceeded for further experimental verification during vaccine designing against coronavirus infection.