Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_27
Snippet: We next sought to address the mechanism of parkin degradation following its association with phospho-Ub. Two previous studies reported that parkin degradation is proteasomal after mitochondrial depolarization [40] , [41] . In agreement with these reports, the proteasomal inhibitor epoxomicin fully abrogated CCCP-induced parkin loss (CCCP: 63.5 ± 7.6% of untreated; CCCP + epoxomicin: 94.5 ± 7.6% of untreated, p = 0.02, N =5) (Fig. 7A) ......
Document: We next sought to address the mechanism of parkin degradation following its association with phospho-Ub. Two previous studies reported that parkin degradation is proteasomal after mitochondrial depolarization [40] , [41] . In agreement with these reports, the proteasomal inhibitor epoxomicin fully abrogated CCCP-induced parkin loss (CCCP: 63.5 ± 7.6% of untreated; CCCP + epoxomicin: 94.5 ± 7.6% of untreated, p = 0.02, N =5) (Fig. 7A) .
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