Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_40
Snippet: To extend our observations with C431S parkin, we treated cells with either L-DOPA or CCCP in the presence or absence of epoxomicin and carried out Western blotting to detect highermolecular weight parkin forms (Fig 7A,B) . In no case did we detect higher-molecular weight parkin bands, consistent with the idea that autoubiquitination is not required for parkin loss......
Document: To extend our observations with C431S parkin, we treated cells with either L-DOPA or CCCP in the presence or absence of epoxomicin and carried out Western blotting to detect highermolecular weight parkin forms (Fig 7A,B) . In no case did we detect higher-molecular weight parkin bands, consistent with the idea that autoubiquitination is not required for parkin loss.
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