Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_9
Snippet: We did not observe enhanced protection of parkin from L-DOPA-induced loss by using higher doses of glutathione or by pre-treating cells with glutathione prior to L-DOPA exposure (Fig. S5 ). This result indicates that oxidative stress is at least partially responsible for L-DOPAinduced parkin loss but that a non-oxidative mechanism may account for about half of this loss......
Document: We did not observe enhanced protection of parkin from L-DOPA-induced loss by using higher doses of glutathione or by pre-treating cells with glutathione prior to L-DOPA exposure (Fig. S5 ). This result indicates that oxidative stress is at least partially responsible for L-DOPAinduced parkin loss but that a non-oxidative mechanism may account for about half of this loss.
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