Author: Yonghua Wu
Title: Strong evolutionary convergence of receptor-binding protein spike between COVID-19 and SARS-related coronaviruses Document date: 2020_3_4
ID: 4ihv80au_14
Snippet: We used 35 coronavirus strain genomes of the subgenus Sarbecovirus based on two published studies 5,6 , including 2019-nCoV, SARS-CoV, and their phylogenetic relative, bat SARS-like CoV (please see Fig. 1 for details). For all these coronavirus strains, we downloaded their full-length genome sequences from GenBank except for five 2019-nCoV and RaTG13 strains, which were downloaded from GISAID. We aligned these genome sequences using MAFFT (https:.....
Document: We used 35 coronavirus strain genomes of the subgenus Sarbecovirus based on two published studies 5,6 , including 2019-nCoV, SARS-CoV, and their phylogenetic relative, bat SARS-like CoV (please see Fig. 1 for details). For all these coronavirus strains, we downloaded their full-length genome sequences from GenBank except for five 2019-nCoV and RaTG13 strains, which were downloaded from GISAID. We aligned these genome sequences using MAFFT (https://mafft.cbrc.jp/alignment/server/). The coding sequences of 11 genes (Fig. 1 ) annotated in the genome of 2019-nCoV (NC_045512) were used as a reference sequence to obtain the homologous gene sequences of the 35 coronavirus strains. We aligned these homologous gene sequences using the online software webPRANK (http://www.ebi.ac.uk/goldman-srv/webprank/) 38 , which is considered to create a more reliable alignment to decrease false-positive results in positive selection analyses 39 .
Search related documents:
Co phrase search for related documents- code sequence and genome sequence: 1
- code sequence and length genome sequence: 1
- coronavirus strain and gene sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- coronavirus strain and genome sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- coronavirus strain and homologous gene sequence: 1
- coronavirus strain and length genome sequence: 1, 2
- coronavirus strain and online software: 1
- coronavirus strain and positive selection: 1
- coronavirus strain and reference sequence: 1
- gene sequence and genome sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71
- gene sequence and homologous gene sequence: 1, 2, 3, 4, 5, 6, 7, 8
- gene sequence and length genome sequence: 1, 2, 3, 4
- gene sequence and online software: 1
- gene sequence and positive selection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- gene sequence and reference sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
- gene sequence and reliable alignment: 1, 2, 3
- genome sequence and homologous gene sequence: 1
- genome sequence and length genome sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61
- genome sequence and online software: 1
Co phrase search for related documents, hyperlinks ordered by date