Selected article for: "nested set and subgenomic nested set"
Author: Wenhao Dai; Bing Zhang; Xia-Ming Jiang; Haixia Su; Jian Li; Yao Zhao; Xiong Xie; Zhenming Jin; Jingjing Peng; Fengjiang Liu; Chunpu Li; You Li; Fang Bai; Haofeng Wang; Xi Cheng; Xiaobo Cen; Shulei Hu; Xiuna Yang; Jiang Wang; Xiang Liu; Gengfu Xiao; Hualiang Jiang; Zihe Rao; Leike Zhang; Yechun Xu; Haitao Yang; Hong Liu
Title: Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease
  • Document date: 2020_3_28
    • ID: b4joa5tx_2
    Snippet: There is an a-1 frameshift between ORF1a and ORF1b which are the first ORF, about two-third of genome length, directly translating polyprotein (pp) 1a/1ab. These polyproteins will be processed by a 3C-like protease (3CL pro ), also named as the main protease (M pro ), and one or two papain-like proteases (PLPs) into 16 non-structural proteins (nsps). Subsequently, these nsps catalyze the synthesis of a nested set of subgenomic RNAs which are used.....
    Document: There is an a-1 frameshift between ORF1a and ORF1b which are the first ORF, about two-third of genome length, directly translating polyprotein (pp) 1a/1ab. These polyproteins will be processed by a 3C-like protease (3CL pro ), also named as the main protease (M pro ), and one or two papain-like proteases (PLPs) into 16 non-structural proteins (nsps). Subsequently, these nsps catalyze the synthesis of a nested set of subgenomic RNAs which are used as templates to directly translate main structural author/funder. All rights reserved. No reuse allowed without permission.

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