Selected article for: "ACE inhibition and potent ACE inhibition"

Author: Deaton, David N.; Graham, Kevin P.; Gross, Jeffrey W.; Miller, Aaron B.
Title: Thiol-based angiotensin-converting enzyme 2 inhibitors: P(1′) modifications for the exploration of the S(1′) subsite
  • Cord-id: zutavvrf
  • Document date: 2008_3_1
  • ID: zutavvrf
    Snippet: Explorations of the S(1′) subsite of ACE2 via modifications of the P(1′) methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.
    Document: Explorations of the S(1′) subsite of ACE2 via modifications of the P(1′) methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.

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