Incidence and risk factors for early readmission after hospitalization for SARS-CoV-2 infection: results from a retrospective cohort study

Kirkegaard, Cristina; Falcó-Roget, Anna; Sánchez-Montalvá, Adrián; Valls, Ángel; Clofent, David; Campos-Varela, Isabel; García-García, Sonia; Leguízamo, Lina María; Sellarès-Nadal, Júlia; Eremiev, Simeon; Villamarín, Miguel; Marzo, Blanca; Almirante, Benito; Len, Òscar

PURPOSE: We aim to assess risk factors related to early readmission in previous hospitalized patients with COVID-19. METHODS: We analyzed a retrospective cohort of patients with laboratory-confirmed COVID-19 admitted to Vall d’Hebron University Hospital, Barcelona, Spain. Early readmission was defined as the need for hospitalization within a period of 60 days after discharge. A descriptive analysis of the readmission was performed, including hospitalization outcome. We also performed a multivariate logistic regression to define risk factors for readmission RESULTS: A total of 629 patients were followed up during 60 days with a readmission cumulative incidence of 5.4% (34 out of 629) and an incidence rate of 0.034 person-years. Main reasons for readmission were respiratory worsening (13, 38.2%), decompensation of previous disease (12, 35.3%) or infectious complications (6, 17.6%). Median time to readmission was 12 days (interquartile range 7–33 days). Prior diagnosis of heart failure (OR 4.09; 95% CI 1.35–12.46; p = 0.013), length of stay during index admission greater than 13 days (OR 2.72; 95% CI 1.21–6.12; p = 0.015), treatment with corticosteroids (OR 2.39; 95% CI 1.01–5.70; p = 0.049) and developing pulmonary thromboembolism (OR 11.59; 95% CI 2.89–46.48; p = 0.001) were the risk factors statistically associated with early readmission. CONCLUSION: Readmission cumulative incidence was 5.4%. Those patients with prior diagnosis of heart failure, length of stay greater than 13 days, treated with corticosteroids or who developed pulmonary thromboembolism might benefit from close monitoring after being discharged.