Symptoms reported by SARS-CoV-2 seropositive and seronegative healthcare and administrative employees in Denmark from May to August 2020

Kaspersen, Kathrine Agergård; Greve, Thomas; Nielsen, Kent Jacob; Jespersen, Sanne; Mikkelsen, Susan; Vestergaard, Jesper Medom; Redder, Jacob Dvinge; Tolstrup, Martin; Thomsen, Marianne Kragh; Møller, Holger Jon; Østergaard, Lars; Kolstad, Henrik Albert; Erikstrup, Christian

Background The distribution and nature of symptoms among SARS-CoV-2 infected individuals need to be clarified. Methods Between May and August 2020, 11,138 healthcare and administrative personnel from Central Denmark Region were tested for SARS-CoV-2 antibodies and subsequently completed a questionnaire. Symptom prevalence and overall duration for symptoms persisting for more than 30 days were calculated. Logistic regression models were used to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs). Results In total, 447 (4%) of the participants were SARS-CoV-2-seropositive. Loss of sense of smell and taste was reported by 50% of seropositives compared with 3% of seronegatives. Additionally, seropositives more frequently reported fever, dyspnoea, muscle or joint ache, fatigue, cough, headache and sore throat, and they were more likely to report symptoms persisting for more than 30 days. In adjusted models, they had a higher risk of reporting symptoms with the strongest association observed for loss of sense of taste and smell (OR = 35.6; 95% CI: 28.6–44.3). Conclusion In this large study, SARS-CoV-2-seropositive participants reported COVID-19-associated symptoms more frequently than those who were seronegative, especially loss of sense of taste and smell. Overall, their symptoms were also more likely to persist for more than 30 days.