Author: Dhurvas Chandrasekaran Dinesh; Dominika Chalupska; Jan Silhan; Vaclav Veverka; Evzen Boura
Title: Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein Document date: 2020_4_5
ID: ezpjdz55_9
Snippet: The structure revealed an RNA duplex bound to the positively charged canyon located between the basic finger and the palm of the N-NTD. A notable feature of the binding interface is its electrostatic potential. It is highly positive with several arginine residues (R92, R107, R149) that directly contact the RNA. Our model also predicts several hydrophobic interactions, such as one involving the side-chains of residues I94 and L104, which also cont.....
Document: The structure revealed an RNA duplex bound to the positively charged canyon located between the basic finger and the palm of the N-NTD. A notable feature of the binding interface is its electrostatic potential. It is highly positive with several arginine residues (R92, R107, R149) that directly contact the RNA. Our model also predicts several hydrophobic interactions, such as one involving the side-chains of residues I94 and L104, which also contribute to RNA binding. Taken together our data provide a molecular snapshot of RNA recognition by the coronaviral N protein and suggest a hot spot located at the interface of the basic finger and the palm as a suitable target for targeting by small molecules.
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