Selected article for: "pathway signal and signaling pathway"
Author: Wondmkun, Yohannes Tsegyie; Mohammed, Ousman Ahmed
Title: A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
  • Cord-id: 1gdjvubp
  • Document date: 2020_8_25
    • ID: 1gdjvubp
    Snippet: Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease-19 (COVID-19) that spreads quickly in the world. Considering the impact of this pandemic, researchers have been racing to understand the peculiar nature of the virus and the pathogenesis of the disease to uncover possible drug targets, effective therapeutic agents, and vaccines. Accordingly, numerous drug targets are identified by scientists. Among them, structural glycoproteins, virulence factors, host-specific receptors
    Document: Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease-19 (COVID-19) that spreads quickly in the world. Considering the impact of this pandemic, researchers have been racing to understand the peculiar nature of the virus and the pathogenesis of the disease to uncover possible drug targets, effective therapeutic agents, and vaccines. Accordingly, numerous drug targets are identified by scientists. Among them, structural glycoproteins, virulence factors, host-specific receptors and enzymes, non-structure proteins, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway, and pro-inflammatory cytokines are discussed herein. This review summarizes the promising drug targets for COVID-19, and highlights antiviral strategies which depend on molecular interactions between viral small molecules and host biologic machinery for repurposing the available clinical drugs. In addition, it gives a strong rational basis for the ongoing discovery of new drugs and vaccines.

    Search related documents:
    Co phrase search for related documents
    • acid synthesis and activator transducer: 1, 2, 3
    • acid synthesis and active site: 1, 2
    • acid synthesis and activity inhibit: 1
    • acid synthesis and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
    • acid synthesis and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4
    • acid synthesis and adenosine triphosphate: 1, 2
    • acid synthesis and lung inflammation: 1
    • activator signal transducer and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
    • activator signal transducer and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • activator signal transducer and lung inflammation: 1, 2, 3, 4, 5, 6, 7
    • activator transducer and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
    • activator transducer and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • activator transducer and lung inflammation: 1, 2, 3, 4, 5, 6, 7
    • active mature and acute respiratory syndrome: 1, 2
    • active mature and acute sars cov respiratory syndrome coronavirus: 1
    • active mature and lung inflammation: 1, 2
    • active mature production and acute respiratory syndrome: 1, 2
    • active mature production and acute sars cov respiratory syndrome coronavirus: 1
    • active mature production and lung inflammation: 1, 2