Author: Jacob W. Myerson; Priyal N. Patel; Nahal Habibi; Landis R. Walsh; Yi-Wei Lee; David C. Luther; Laura T. Ferguson; Michael H. Zaleski; Marco E. Zamora; Oscar A. Marcos-Contreras; Patrick M. Glassman; Ian Johnston; Elizabeth D. Hood; Tea Shuvaeva; Jason V. Gregory; Raisa Y. Kiseleva; Jia Nong; Kathryn M. Rubey; Colin F. Greineder; Samir Mitragotri; George S. Worthen; Vincent M. Rotello; Joerg Lahann; Vladimir R. Muzykantov; Jacob S. Brenner
Title: Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment Document date: 2020_4_18
ID: ezrkg0dc_28
Snippet: The data presented in figure 3 and supplementary figures 8-13 indicate that a variety of protein-based nanostructures have tropism for acute inflammatory injury in the lungs. NPs based on agglutination of proteins in non-site-specific interactions (NAPs, Figure 3A -C, Supplementary Figures 8-10 ) all exhibited either significant increases in lung uptake after LPS injury or high levels of lung uptake in both naïve control and LPSinjured animals. .....
Document: The data presented in figure 3 and supplementary figures 8-13 indicate that a variety of protein-based nanostructures have tropism for acute inflammatory injury in the lungs. NPs based on agglutination of proteins in non-site-specific interactions (NAPs, Figure 3A -C, Supplementary Figures 8-10 ) all exhibited either significant increases in lung uptake after LPS injury or high levels of lung uptake in both naïve control and LPSinjured animals. Nanostructures based on highly symmetrical protein organization had no specific tropism for inflamed lungs ( Figure 3D ). Representative nanostructures not based on proteins, bare liposomes and polystyrene beads, did not home to inflamed lungs ( Figure 3E ).
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