Author: Brito, Luana San de O; Pinto, Francisco das Chagas L; de Filho, Manoel Odorico M; Rocha, Danilo D; Mendoza, Maria Fernanda M; Ayala, Alejandro Pedro; Bezerra, Beatriz Pinheiro; Loiola, Maria Iracema B; Canuto, Kirley M; Silveira, Edilberto R; Pessoa, Otilia Deusdenia L
Title: Tropane alkaloids from the stem bark of Erythroxylum bezerrae. Cord-id: 1lupjvi9 Document date: 2020_10_1
ID: 1lupjvi9
Snippet: Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activit
Document: Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively.
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