Author: Bing-peng Lin; Mei Zhong; Hong-bin Gao; Kai-bin Wu; Ming-xiao Liu; Chang Liu; Xin-hong Wang; Jian-ming Chen; Learn-han Lee; Cui-ling Qi; Lin-hu Ge; Li-jing Wang
Title: Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry Document date: 2020_4_18
ID: 0vqzlurx_2
Snippet: Similar to those of patients with SARS and MERS, the clinical manifestations of COVID-19 at illness onset are fever, dry cough, and myalgia. The patients may suffer from dyspnea, shortness of breath, and then respiratory failure and even death in later stages [2, 6, 7] . Previous findings indicated that the ACE2 plays an important role in cellular entry, thus ACE2-expressing cells may act as target cells and are susceptible to COVID-19 infection .....
Document: Similar to those of patients with SARS and MERS, the clinical manifestations of COVID-19 at illness onset are fever, dry cough, and myalgia. The patients may suffer from dyspnea, shortness of breath, and then respiratory failure and even death in later stages [2, 6, 7] . Previous findings indicated that the ACE2 plays an important role in cellular entry, thus ACE2-expressing cells may act as target cells and are susceptible to COVID-19 infection [2, 8, 9, 10,] . Besides, ACE2 receptor was proven to be expressed in 72 human tissues, and is abundantly present in the epithelia of the lung and small intestines [11] . Studies also found ACE2 expression in the epithelial layer of nasal and oral mucosa. However, this conclusion was based on the bulk RNA datasets. The cell type and number of cells expressing ACE2 in each tissue could not be estimated.
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