Author: Bing-peng Lin; Mei Zhong; Hong-bin Gao; Kai-bin Wu; Ming-xiao Liu; Chang Liu; Xin-hong Wang; Jian-ming Chen; Learn-han Lee; Cui-ling Qi; Lin-hu Ge; Li-jing Wang
Title: Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry Document date: 2020_4_18
ID: 0vqzlurx_23
Snippet: As ACE2 had been proven to be one of the major receptors of COVID-2019 in human body, we explored the online datasets to find out the expression level of ACE2 in oral mucosa. As expected, data from GEO indicated that ACE2 receptor expression . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.18.047951 doi: bi.....
Document: As ACE2 had been proven to be one of the major receptors of COVID-2019 in human body, we explored the online datasets to find out the expression level of ACE2 in oral mucosa. As expected, data from GEO indicated that ACE2 receptor expression . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.18.047951 doi: bioRxiv preprint level was relatively higher in epithelial cells (cluster 1, 4, 5) (Fig. 3A, 3B) , while very little cellular expression of ACE2 was found in fibroblasts (cluster 2). Then we calculated the percent of ACE2-expressing cells in the dataset (Fig. 3C) . We find that, in oral tissue, the percentage of ACE2-positive cells was 2.2%. Among them, 92% were epithelial cells.
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