Selected article for: "cell furin and host cell entry"
Author: Bing-peng Lin; Mei Zhong; Hong-bin Gao; Kai-bin Wu; Ming-xiao Liu; Chang Liu; Xin-hong Wang; Jian-ming Chen; Learn-han Lee; Cui-ling Qi; Lin-hu Ge; Li-jing Wang
Title: Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry
  • Document date: 2020_4_18
    • ID: 0vqzlurx_35
    Snippet: Previous reports had demonstrated that FURIN protein was expressed in metastasizing OSCCs [31] . Besides, FURIN was expressed in normal epithelium and up-regulated in SCCs from three different organs [22] . But the relative report of FURIN protein expression in normal oral cavity was limited. For further validating the results in the gene level, FURIN immunohistochemistry was therefore performed on conventional sections for the first time to asse.....
    Document: Previous reports had demonstrated that FURIN protein was expressed in metastasizing OSCCs [31] . Besides, FURIN was expressed in normal epithelium and up-regulated in SCCs from three different organs [22] . But the relative report of FURIN protein expression in normal oral cavity was limited. For further validating the results in the gene level, FURIN immunohistochemistry was therefore performed on conventional sections for the first time to assess its expression in oral mucosa obtained from five different sites. It is noteworthy that moderate positive expression of FURIN protein were observed in tongue, giniva and lip, while weakly positive in the buccal and palatal tissues. As a result, we speculated that SARS-CoV-2 could fuse with the FURIN enzyme on the cell membrane the oral mucosal cells, then entry into the host cells. Alternatively, FURIN could be recognised as the potential drug target of suppressing the infection of new coronavirus.

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