Author: Yan Gao; Liming Yan; Yucen Huang; Fengjiang Liu; Yao Zhao; Lin Cao; Tao Wang; Qianqian Sun; Zhenhua Ming; Lianqi Zhang; Ji Ge; Litao Zheng; Ying Zhang; Haofeng Wang; Yan Zhu; Chen Zhu; Tianyu Hu; Tian Hua; Bing Zhang; Xiuna Yang; Jun Li; Haitao Yang; Zhijie Liu; Wenqing Xu; Luke W. Guddat; Quan Wang; Zhiyong Lou; Zihe Rao
Title: Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target Document date: 2020_3_17
ID: glfxrla9_9
Snippet: Remdesivir, the single Sp isomer of the 2-ethylbutyl L-alaninate phosphoramidate prodrug (15) ( fig. S7 ), has been reported to inhibit 2019-nCoV proliferation and have potential to treat patients 40 in the clinic (7, 8). The efficacy of chain-terminating nucleotide analogs requires viral RdRps to recognize and successfully incorporate the active form of the inhibitors into the growing RNA strand. Because of the structural conservation on the pol.....
Document: Remdesivir, the single Sp isomer of the 2-ethylbutyl L-alaninate phosphoramidate prodrug (15) ( fig. S7 ), has been reported to inhibit 2019-nCoV proliferation and have potential to treat patients 40 in the clinic (7, 8). The efficacy of chain-terminating nucleotide analogs requires viral RdRps to recognize and successfully incorporate the active form of the inhibitors into the growing RNA strand. Because of the structural conservation on the polymerase catalytic chamber between 2019-nCoV and HCV ns5b polymerase, as well as the likely similar mechanisms of action of remdesivir and sofosbuvir (12, 16) (2'-F-2'-C-methyluridine monophosphate prodrug which targets HCV 45 author/funder. All rights reserved. No reuse allowed without permission.
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